The Ministry of Health and Welfare of Japan issued a correction plan for the "Food and Drug List" on March 23 last year and solicited opinions. The correction plan plans to combine the white Shouwu and D- β- Hydroxybutyric acid is added to the "list of ingredients (raw materials) of drugs" (food and drug list) if it does not advertise the function and efficacy of drugs.
The so-called ketone body is D- β- Hydroxybutyric acid (BHB), when the sugar of the energy source in the body is exhausted, will form ketone body as the energy source. BHB has a variety of physiological functions. Recent studies have shown that it is an energy source superior to sugar, and has anti-aging effect on the vascular system. This effect can reduce and alleviate vascular related diseases, such as cardiovascular disease, Alzheimer's disease, etc. At present, as the raw material of dietary supplements, it has attracted the attention of the market.
Milk, liver and other foods contain trace amounts of D- β- Hydroxybutyric acid, however, is very difficult to absorb in large quantities from food, and is sold as a dietary supplement in Europe and America. A molecule produced during fasting or calorie restriction has anti-aging effect on the vascular system, which can reduce and alleviate vascular diseases, such as cardiovascular diseases. As people grow older, they are more prone to cancer, cardiovascular disease and Alzheimer's disease. Aging is the most important pathogenic factor of human diseases. How to really delay aging is the main way to reduce and alleviate human diseases. Vascular aging is the most important part of aging. With the growth of age, the blood vessels supplying different organs are the most sensitive and more vulnerable to aging damage. Therefore, it is very important to study the aging of blood vessels. This kind of name is β- Hydroxybutyric acid（ β- Hydroxybutyrate) is a small molecule of ketone body (or water-soluble molecule containing ketone group), which is produced from fatty acids in the liver and is produced during low food intake, carbohydrate restriction diet, hunger and long-term vigorous exercise., β- Hydroxybutyric acid can delay the aging of blood vessels, which actually provides a chemical link for calorie restriction, fasting and delaying aging. This compound can delay the aging of blood vessels by arranging endothelial cells on the inner surface of blood vessels and lymphatic vessels. It can prevent a type of aging called cell senescence (sensenesce or cellular aging), that is, cells have functions but exit the cell cycle. " Aging cells cannot divide again.
In addition, when β- When hydroxybutyric acid is combined with specific RNA binding protein, it will increase the activity of transcription factor Oct4 (a kind of stem cell factor) in mouse vascular smooth muscle and endothelial cells. OCT4 will increase a key factor to resist the aging induced by DNA damage and keep the blood vessels young.
This stem cell factor (OCT4) may be a drug or pharmacological target to slow or prevent aging. If the vascular system becomes younger, it is less likely to suffer from cardiovascular disease, Alzheimer's disease and cancer, because all these diseases are related to aging.